What is Histamine Intolerance?

📅 Published October 15, 2025

Understanding the basics of histamine intolerance, its causes, and common symptoms.

Understanding Histamine Intolerance

Histamine intolerance occurs when there is an imbalance between accumulated histamine and the body's ability to break it down. Unlike a food allergy, histamine intolerance is a digestive issue where the body cannot properly process histamine from foods.

What is Histamine?

Histamine is a chemical compound that plays important roles in your immune system, digestion, and nervous system. It's naturally present in many foods and is also produced by your body.

Common Symptoms

  • Headaches and migraines
  • Digestive issues (bloating, diarrhea, abdominal pain)
  • Skin problems (hives, eczema, itching)
  • Respiratory issues (nasal congestion, asthma-like symptoms)
  • Irregular heartbeat or rapid heart rate
  • Anxiety and sleep disturbances
  • Fatigue

Causes of Histamine Intolerance

The primary cause is a deficiency in diamine oxidase (DAO), the enzyme responsible for breaking down histamine in the digestive tract. Other factors include:

  • Genetic predisposition
  • Gut health issues
  • Certain medications that block DAO
  • Bacterial overgrowth

Diagnosis and Treatment

Diagnosis can be challenging as symptoms overlap with other conditions. Treatment typically involves following a low-histamine diet and addressing underlying gut health issues.

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Medical Disclaimer

This article is for educational purposes only and does not constitute medical advice. Always consult with a qualified healthcare professional before making changes to your diet or treatment plan.

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