Understanding DAO Enzyme
Diamine oxidase (DAO) is the primary enzyme responsible for breaking down ingested histamine in your digestive system. When DAO levels are low or the enzyme isn't functioning properly, histamine can accumulate and cause symptoms.
What Affects DAO Levels?
- Genetics: Some people naturally produce less DAO
- Gut Health: DAO is produced in the intestinal lining
- Medications: Some drugs block DAO activity
- Nutrient Deficiencies: DAO requires certain vitamins and minerals to function
Medications That Block DAO
Be aware that certain medications can interfere with DAO enzyme activity:
- Some antibiotics
- Antidepressants
- Pain medications (NSAIDs)
- Antacids
Supporting DAO Function Naturally
Several nutrients are essential for DAO production and function:
- Vitamin B6: Critical cofactor for DAO
- Vitamin C: Helps degrade histamine and supports DAO
- Copper: Required for DAO activity
- Zinc: Supports enzyme function
DAO Supplements
DAO enzyme supplements taken before meals can help break down histamine in food. They work best when taken 15-20 minutes before eating. While they can be helpful, addressing the root cause of DAO deficiency is important for long-term management.